Description

2,3-Difluoro-4-(trifluoromethyl)benzonitrile is a high-value fluorinated aromatic nitrile building block. This compound is critical for introducing multiple fluorine atoms and a reactive nitrile group into complex molecular architectures, enabling precise tuning of electronic and physical properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics where fluorine substitution enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl and difluoro motifs contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to desired dielectric anisotropy and thermal stability.
• Polymer & Functional Material Modifier: Incorporated into specialty polymers to impart unique chemical resistance, low surface energy, or specific optical properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, cyano group transformations, and as a scaffold for constructing complex, multi-fluorinated heterocycles in medicinal chemistry.

Basic Information

Product Name	2,3-Difluoro-4-(trifluoromethyl)benzonitrile
CAS No.	240122-24-1
Molecular Formula	C8H2F5N
Molecular Weight	207.10 g/mol
Synonyms	2,3-Difluoro-4-(trifluoromethyl)benzonitrile; 4-Cyano-2,3-difluorobenzotrifluoride; 2,3-Difluoro-α,α,α-trifluoro-p-tolunitrile; 2,3-Difluoro-4-trifluoromethylbenzonitrile; Benzonitrile, 2,3-difluoro-4-(trifluoromethyl)-; 240122-24-1
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.