Description

2-Fluoro-4-(trifluoromethyl)phenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both fluorine and a trifluoromethyl group, imparts unique electronic and steric properties that are highly valuable for modulating the activity and physicochemical profile of target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the construction of complex, high-value intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting novel therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the development of organic semiconductors and other electronic materials due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl systems.
• General Organic Synthesis: A valuable building block for constructing diverse heterocycles and functionalized aromatic compounds in academic and industrial R&D.

Basic Information

Product Name	2-Fluoro-4-(trifluoromethyl)phenylacetonitrile
CAS No.	239087-11-7
Molecular Formula	C9H5F4N
Molecular Weight	203.14 g/mol
Synonyms	2-Fluoro-α-(trifluoromethyl)benzeneacetonitrile; (2-Fluoro-4-(trifluoromethyl)phenyl)acetonitrile; 2-Fluoro-4-(trifluoromethyl)benzyl cyanide; α-Cyano-2-fluoro-4-(trifluoromethyl)toluene; 4-(Trifluoromethyl)-2-fluorophenylacetonitrile; 2-Fluoro-4-trifluoromethylphenylacetonitrile; 239087-11-7; FFP-acetonitrile (abbrev.)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(trifluoromethyl)phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.