Description

3,4-Difluoro-5-(Trifluoromethyl)Benzonitrile is a high-value, multi-fluorinated aromatic nitrile building block essential for advanced chemical synthesis. Its unique structure, featuring both difluoro and trifluoromethyl substituents, provides exceptional electronic and steric properties that are critical for modulating the bioactivity and physicochemical characteristics of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex fluorinated aromatic systems.
• Material Science Research: Employed in the development of novel fluorinated materials for coatings, membranes, and advanced composites.

Basic Information

Product Name	3,4-Difluoro-5-(Trifluoromethyl)Benzonitrile
CAS No.	236736-22-4
Molecular Formula	C8H2F5N
Molecular Weight	207.10 g/mol
Synonyms	5-(Trifluoromethyl)-3,4-difluorobenzonitrile; 3,4-Difluoro-5-(trifluoromethyl)benzonitrile; 2,3-Difluoro-6-cyanobenzotrifluoride; 2,3-Difluoro-α,α,α-trifluoro-p-tolunitrile; Benzonitrile, 3,4-difluoro-5-(trifluoromethyl)-; 236736-22-4; 5-Cyano-1,2-difluoro-3-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Every batch of 3,4-Difluoro-5-(Trifluoromethyl)Benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying identity, purity (typically ≥97% by HPLC), and impurity profile is supplied with each shipment to guarantee reproducible performance and supply chain traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.