Description

3-Fluoro-4-(Trifluoromethyl)Benzonitrile is a high-value fluorinated aromatic nitrile building block, essential for introducing both fluorine and trifluoromethyl substituents into complex molecular architectures. Its unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where electronic and steric properties are finely tuned. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides with improved efficacy and environmental profiles.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes.
• Polymer & Resin Modifier: Imparts specific chemical resistance and stability properties when incorporated into high-performance polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed coupling reactions to create complex biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	3-Fluoro-4-(Trifluoromethyl)Benzonitrile
CAS No.	231953-38-1
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	4-Cyano-2-fluoro-1-(trifluoromethyl)benzene; 2-Fluoro-α,α,α-trifluoro-p-tolunitrile; 3-Fluoro-4-(trifluoromethyl)benzonitrile; 2-Fluoro-4-cyanobenzotrifluoride; 4-(Trifluoromethyl)-3-fluorobenzonitrile; 2-Fluoro-α,α,α-trifluoro-4-cyanotoluene; 3-Fluoro-4-trifluoromethylbenzonitrile; 4-Cyano-2-fluorobenzotrifluoride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support development from research quantities to commercial scale with reliable supply and full regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.