Description

3,5-Difluoro-4-(Hydroxymethyl)Benzonitrile is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a hydroxymethyl group and a nitrile function on a difluorinated benzene core, makes it a valuable precursor for constructing complex molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries. It serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens used in advanced display technologies.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for creating specialty polymers with unique thermal and chemical resistance properties.
• Organic Synthesis Reagent: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution due to its reactive fluorine atoms.
• Material Science Research: Acts as a starting material for creating novel organic semiconductors and non-linear optical (NLO) materials.

Basic Information

Product Name	3,5-Difluoro-4-(Hydroxymethyl)Benzonitrile
CAS No.	228421-83-8
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	4-(Hydroxymethyl)-3,5-difluorobenzonitrile; 3,5-Difluoro-4-(hydroxymethyl)benzonitrile; Benzonitrile, 3,5-difluoro-4-(hydroxymethyl)-; 2,6-Difluoro-4-(cyanomethyl)phenol (tautomeric form); 4-Cyanomethyl-2,6-difluorophenol
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(Hydroxymethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.