Description

2-Chloro-6-Fluoro-3-Nitrobenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of its chloro, fluoro, and nitro substituents, which allow for selective and sequential functionalization. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a substituted benzonitrile core with halogen and nitro handles for further derivatization.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro and nitrile groups.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for creating molecular probes, enzyme inhibitors, and other tool compounds in life science research.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing complex, color-fast azo dyes and organic pigments.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) due to the reactive chlorine atom, enabling efficient carbon-carbon and carbon-heteroatom bond formation.

Basic Information

Product Name	2-Chloro-6-Fluoro-3-Nitrobenzonitrile
CAS No.	226419-18-7
Molecular Formula	C7H2ClFN2O2
Molecular Weight	200.55 g/mol
Synonyms	2-Chloro-6-fluoro-3-nitrobenzonitrile; Benzonitrile, 2-chloro-6-fluoro-3-nitro-; 3-Nitro-2-chloro-6-fluorobenzonitrile; 226419-18-7; 2-Chloro-6-fluorobenzonitrile-3-nitro; 6-Fluoro-2-chloro-3-nitrobenzonitrile; 2-Chloro-6-fluoro-3-nitro-benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluoro-3-Nitrobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality ensures the material is suitable for demanding applications in cGMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere if possible and opened only in a controlled, dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.