Description

4-(Bromomethyl)-2-Fluorobenzonitrile is a versatile and high-purity fluorinated aromatic building block. This compound is valued for its dual reactive sites, the bromomethyl and nitrile groups, which facilitate its use in advanced synthetic pathways. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for constructing complex molecular architectures, including active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used to introduce fluorinated benzyl motifs into novel herbicides, fungicides, and insecticides to enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the development of advanced organic electronic materials and liquid crystals due to its fluorinated aromatic core.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom chemical synthesis services targeting complex, multi-step organic transformations.

Basic Information

Product Name	4-(Bromomethyl)-2-Fluorobenzonitrile
CAS No.	222978-03-2
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	2-Fluoro-4-(bromomethyl)benzonitrile; 4-Bromomethyl-2-fluorobenzonitrile; α-Bromo-2-fluoro-p-tolunitrile; 2-Fluoro-4-(bromomethyl)phenyl cyanide; (4-Cyano-3-fluorophenyl)methyl bromide; 2-Fluoro-4-(bromomethyl)benzenecarbonitrile; p-(Bromomethyl)-o-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our production of 4-(Bromomethyl)-2-Fluorobenzonitrile adheres to stringent quality management protocols. Each batch is characterized and tested to ensure high chemical purity and consistency, with typical purity levels exceeding 97% (HPLC). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.