Description

2-Fluoro-4-(Hydroxymethyl)Benzonitrile is a versatile fluorinated aromatic nitrile building block, distinguished by the presence of a hydroxymethyl functional group. This unique bifunctional structure makes it a critical intermediate for synthesizing complex molecules in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS-targeted drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in display technologies.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialty polymers with specific thermal and chemical resistance properties.
• Organic Synthesis Building Block: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic substitution reactions due to its reactive cyano and benzylic hydroxyl groups.
• Material Science Research: Employed in the development of organic semiconductors and photoactive materials.

Basic Information

Product Name	2-Fluoro-4-(Hydroxymethyl)Benzonitrile
CAS No.	222978-02-1
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	4-(Hydroxymethyl)-2-fluorobenzonitrile; 2-Fluoro-4-(hydroxymethyl)benzonitrile; 2-Fluoro-4-cyanobenzyl alcohol; 4-Cyano-3-fluorobenzyl alcohol; (4-Cyano-3-fluorophenyl)methanol; Benzonitrile, 2-fluoro-4-(hydroxymethyl)-; 2-Fluoro-4-hydroxymethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Hydroxymethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.