Description

2,3-Difluoro-6-Methoxybenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring strategically placed fluorine and methoxy substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro-methoxy motif can enhance biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting applications.
• Functional Polymer Monomer: Employed in the creation of specialty polymers with specific chemical resistance, thermal stability, or optical properties.
• Chemical Research & Development: A valuable building block for academic and industrial R&D in organic chemistry, catalysis, and material science.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	2,3-Difluoro-6-Methoxybenzonitrile
CAS No.	221202-34-2
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	6-Methoxy-2,3-difluorobenzonitrile; 2,3-Difluoro-6-methoxybenzenecarbonitrile; Benzonitrile, 2,3-difluoro-6-methoxy-; 2,3-Difluoro-6-methoxy-benzonitrile; 221202-34-2
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-6-Methoxybenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming the product meets the agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for regulatory filings and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.