Description

6-Difluoromethoxy-2,3-Difluoro-Benzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique substitution pattern, featuring both difluoromethoxy and difluoro groups on the benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics where fluorine substitution is used to modulate metabolism, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for display technologies, leveraging its rigid, polarizable aromatic structure.
• Organic Electronic Materials: Employed as a building block for electron-deficient units in the development of organic semiconductors, n-type materials, and non-fullerene acceptors for photovoltaic applications.
• Cross-Coupling Reactions: The nitrile and halogenated (fluoro) sites provide handles for versatile metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl and heteroaryl systems.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination methodologies and the effects of polyfluorination on aromatic systems in academic and industrial R&D settings.

Basic Information

Product Name	6-Difluoromethoxy-2,3-Difluoro-Benzonitrile
CAS No.	221202-16-0
Molecular Formula	C8H3F4NO
Molecular Weight	205.11 g/mol
Synonyms	2,3-Difluoro-6-(difluoromethoxy)benzonitrile; Benzonitrile, 2,3-difluoro-6-(difluoromethoxy)-; 2,3,6-Trifluorobenzonitrile, 6-difluoromethoxy- (ambiguous); DFMO-BF Benzonitrile (abbrev.); 6-(Difluoromethoxy)-2,3-difluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 6-Difluoromethoxy-2,3-Difluoro-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for scale-up and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/GC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.