Description

2-(Difluoromethoxy)-6-Fluoro-Benzonitrile is a high-purity fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique difluoromethoxy and fluoro substituents make it a critical intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoromethoxy group enhances metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, contributing to thermal stability and optical properties.
• Fluorination Chemistry: A valuable reagent in medicinal chemistry for structure-activity relationship (SAR) studies, exploring the effects of fluorine and difluoromethoxy groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	2-(Difluoromethoxy)-6-Fluoro-Benzonitrile
CAS No.	221202-14-8
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	6-Fluoro-2-(difluoromethoxy)benzonitrile; 2,6-Difluoromethoxybenzonitrile; 2-Fluoro-6-(difluoromethoxy)benzonitrile; Benzonitrile, 2-(difluoromethoxy)-6-fluoro-; 221202-14-8; 2-(Difluoromethoxy)-6-fluorobenzonitrile; 6-Fluoro-2-difluoromethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-6-Fluoro-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.