Description

Vantas is a high-purity synthetic peptide derivative used primarily as a controlled-release gonadotropin-releasing hormone (GnRH) agonist in pharmaceutical development and research. It delivers sustained, predictable hormonal modulation critical for preclinical studies and formulation optimization. This compound is essential for contract research organizations (CROs), generic drug developers, and API manufacturers requiring reproducible, GMP-aligned reference standards and active pharmaceutical ingredients. Vantas CAS NO 220810-26-4 supports robust process validation and regulatory submission packages across global markets.

Application

• Active pharmaceutical ingredient (API) in long-term subcutaneous implant formulations for prostate cancer and central precocious puberty
• Reference standard for HPLC and LC-MS method development and validation in pharmaceutical quality control labs
• Research tool for endocrinology and reproductive pharmacology studies evaluating GnRH receptor binding kinetics and downstream signaling pathways
• Key intermediate in the synthesis of degradable polymeric delivery systems for peptide-based therapeutics
• Stability-indicating assay component for forced degradation studies (hydrolysis, oxidation, thermal stress)
• Calibration material for bioanalytical assays quantifying plasma/serum Vantas concentrations in clinical pharmacokinetic trials
• Excipient compatibility testing with biodegradable polymers (e.g., PLGA) in implant matrix development
• GMP-compliant raw material for FDA-submitted ANDA and EU MAA dossiers requiring full traceability and COA documentation

Basic Information

Product Name	Vantas
CAS No.	220810-26-4
Molecular Formula	C73H105N17O15
Molecular Weight	1492.72 g/mol
Synonyms	His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NHCH(CH2CH(CH3)2)COOH; Leuprolide acetate analog; Tryptorelin impurity B; [6-(Nε-Carbamoyl-L-lysine)]-leuprolide; Leuprorelin acetate variant; Vantas® (brand name); 6-Carba-Leuprolide; Des-Gly10,[D-Ala6]-LHRH ethylamide
EINECS	Not listed (new substance under REACH)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to USP General Chapter <1086> for peptide purity, ICH Q5C for structural characterization, and ISO 9001:2015 certified manufacturing protocols. Testing includes identity confirmation by FTIR and NMR, assay by HPLC-UV, and residual solvent analysis per ICH Q3C.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8°C under inert atmosphere (nitrogen or argon) to prevent oxidation and moisture uptake. Maintain relative humidity below 30% during handling and storage. Avoid repeated freeze-thaw cycles. Keep away from strong acids, organic solvents, and fluoride-containing reagents.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0–102.0%
Related Substances	≤ 1.5% total impurities
Single Impurity	≤ 0.5%
Residual Solvents (Acetonitrile)	≤ 410 ppm
Water (Karl Fischer)	≤ 5.0%
Heavy Metals	≤ 10 ppm
Microbial Limits	Total aerobic count ≤ 100 CFU/g; Absence of E. coli, Salmonella, P. aeruginosa, S. aureus

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.