Description

Hydrocortisone 17-Hemisuccinate is a key pharmaceutical intermediate, specifically a hemisuccinate ester derivative of hydrocortisone. This chemical modification is crucial for enhancing the solubility and bioavailability of the parent corticosteroid, enabling its formulation into various injectable and topical medicinal products. It is an essential building block for pharmaceutical manufacturers and research institutions developing advanced corticosteroid therapies, anti-inflammatory agents, and diagnostic reagents.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of water-soluble hydrocortisone prodrugs and active pharmaceutical ingredients (APIs).
• Injectable Corticosteroid Formulations: Enables the production of soluble salts (e.g., sodium succinate) for emergency injectable solutions used in treating severe inflammation, allergic reactions, and adrenal insufficiency.
• Topical & Ophthalmic Preparations: Serves as a precursor in the development of advanced topical creams, ointments, and eye drops with improved skin/ocular penetration.
• Biochemical Research: Used as a standard or reagent in steroid metabolism studies, receptor binding assays, and immunological research.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory and immunosuppressive treatments for animals.
• Diagnostic Kits: Can be utilized in the development of immunoassay kits for the detection and quantification of cortisol and related steroids.

Basic Information

Item	Detail
Product Name	Hydrocortisone 17-Hemisuccinate
CAS No.	220489-73-6
Molecular Formula	C25H34O8
Molecular Weight	462.53 g/mol
Synonyms	Cortisol 17-hemisuccinate; Hydrocortisone 21-hemisuccinate (common naming); 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 17-hemisuccinate; 17-Hydroxycorticosterone 17-hemisuccinate; Cortisol 17-(hydrogen succinate); Hydrocortisone hydrogen succinate; Prednisolone 17-hemisuccinate related compound (Note: This is a common related substance name in specifications).
EINECS	Contact for details

Quality Control

Our Hydrocortisone 17-Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and control of specific impurities and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP and relevant pharmacopeial guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.