Description

3-Methoxy-2,4-Difluorobenzonitrile is a versatile fluorinated aromatic nitrile building block. This compound is valued for its unique substitution pattern, which makes it a critical intermediate in the synthesis of complex molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the synthesis of electron-deficient units for organic semiconductors and OLED materials.
• Cross-Coupling Reactions: The nitrile and halogen groups make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research: Used as a standard or building block in academic and industrial R&D for method development and library synthesis.

Basic Information

Product Name	3-Methoxy-2,4-Difluorobenzonitrile
CAS No.	220353-20-8
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	2,4-Difluoro-3-methoxybenzonitrile; Benzonitrile, 2,4-difluoro-3-methoxy-; 3-Methoxy-2,4-difluorobenzonitrile; 2,4-Difluoro-3-methoxybenzonitrile; 220353-20-8
EINECS	Contact for details

Quality Control

Our 3-Methoxy-2,4-Difluorobenzonitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee it meets the stringent requirements of advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.