Description

2-Fluoro-5-(Trifluoromethyl)Benzyl Bromide is a high-value, multi-functional benzyl bromide derivative distinguished by its unique fluorine and trifluoromethyl substitution pattern. This compound serves as a critical building block in advanced organic synthesis, enabling the introduction of a reactive benzyl moiety under mild conditions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the fluorine atoms.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphine ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and organic electronic materials due to its aromatic and halogenated structure.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form biaryl structures.
• Derivatization Agent: Useful for the benzylation of nucleophiles such as alcohols, thiols, and amines in medicinal chemistry programs.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)Benzyl Bromide
CAS No.	220239-69-0
Molecular Formula	C8H5BrF4
Molecular Weight	257.03 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-5-(trifluoromethyl)benzene; α-Bromo-2-fluoro-α,α,α-trifluoro-p-xylene; 2-Fluoro-α-(bromomethyl)benzotrifluoride; (2-Fluoro-5-(trifluoromethyl)phenyl)methyl bromide; 5-(Bromomethyl)-2-fluorobenzotrifluoride; 2-Fluoro-5-trifluoromethylbenzyl bromide
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(Trifluoromethyl)Benzyl Bromide is manufactured and tested under a strict quality management system. We guarantee high purity and batch-to-batch consistency through comprehensive analytical techniques including GC, HPLC, and NMR. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profiles is supplied with each shipment to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.