Description

4-Fluoro-3-(trifluoromethyl)phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its unique trifluoromethyl and fluorine substituents impart desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance efficacy and environmental profile.
• Liquid Crystal Materials: Used in the development of fluorinated components for advanced display technologies.
• Organic Electronic Materials: Serves as a starting material for electron-transport layers and other functional materials in OLEDs and organic photovoltaics.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Sonogashira) to create biaryl structures.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and creating compound libraries for drug discovery.

Basic Information

Product Name	4-Fluoro-3-(trifluoromethyl)phenylacetonitrile
CAS No.	220239-65-6
Molecular Formula	C9H5F4N
Molecular Weight	203.14 g/mol
Synonyms	2-(4-Fluoro-3-(trifluoromethyl)phenyl)acetonitrile; (4-Fluoro-3-trifluoromethylphenyl)acetonitrile; 4-Fluoro-α-(trifluoromethyl)benzeneacetonitrile; 2-(4-Fluoro-3-trifluoromethylphenyl)ethanenitrile; 4-Fluoro-3-trifluoromethylbenzyl cyanide; α-Cyano-4-fluoro-3-trifluoromethyltoluene; 220239-65-6; 4-Fluoro-3-(trifluoromethyl)benzyl cyanide
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-(trifluoromethyl)phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.