Description

3,4,5-Trifluorophenylacetonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its value lies in the unique reactivity of the nitrile group and the electron-withdrawing properties imparted by the trifluoromethyl pattern on the phenyl ring, enabling precise molecular construction. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and pesticides where fluorine substitution enhances bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated components for electronic display and lighting technologies.
• Functional Polymer Monomer: Serves as a precursor for specialty polymers with tailored chemical resistance and thermal properties.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and cyano-group transformations.
• Chemical Research & Development: Fundamental material for exploring new fluorination chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	3,4,5-Trifluorophenylacetonitrile
CAS No.	220228-03-5
Molecular Formula	C8H4F3N
Molecular Weight	177.12 g/mol
Synonyms	2-(3,4,5-Trifluorophenyl)acetonitrile; (3,4,5-Trifluorophenyl)acetonitrile; 3,4,5-Trifluorobenzeneacetonitrile; α-Cyano-3,4,5-trifluorotoluene; 3,4,5-Trifluorophenyl cyanomethyl; 220228-03-5; 3,4,5-Trifluorobenzyl cyanide
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorophenylacetonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and reducing agents. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.