Description

2-Fluoro-5-(trifluoromethyl)phenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both fluorine and a trifluoromethyl group, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Acts as a building block for fluorinated liquid crystals, which are essential components in advanced display technologies due to their improved stability and electro-optical properties.
• Functional Polymer Monomers: Incorporated into specialty polymers to impart unique chemical resistance, low surface energy, and optical clarity for coatings and high-performance plastics.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electron-transport materials for OLEDs and photovoltaic cells.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and constructing complex molecular architectures in academic and industrial R&D settings.

Basic Information

Product Name	2-Fluoro-5-(trifluoromethyl)phenylacetonitrile
CAS No.	220227-59-8
Molecular Formula	C9H5F4N
Molecular Weight	203.14 g/mol
Synonyms	2-Fluoro-α-(trifluoromethyl)benzeneacetonitrile; (2-Fluoro-5-(trifluoromethyl)phenyl)acetonitrile; 2-Fluoro-5-(trifluoromethyl)benzyl cyanide; α-Cyano-2-fluoro-5-(trifluoromethyl)toluene; 2-Fluoro-5-trifluoromethylphenylacetonitrile; 5-(Trifluoromethyl)-2-fluorophenylacetonitrile; [2-Fluoro-5-(trifluoromethyl)phenyl]acetonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(trifluoromethyl)phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency meet the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.