Description

n-Desacetyl-n-Formyl Thiocolchicoside is a chemically modified derivative of the natural alkaloid thiocolchicoside, representing a key intermediate in advanced pharmaceutical synthesis. This compound is valued for its role in the research and development of novel muscle relaxants and anti-inflammatory agents, offering a pathway to more potent or selective therapeutic candidates. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation thiocolchicoside analogs and related bioactive molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new pharmacological profiles for musculoskeletal disorders.
• Process Development: Serves as a reference standard and key intermediate in optimizing scalable manufacturing routes for active pharmaceutical ingredients (APIs).
• Analytical Standard: Employed as a high-purity reference material in quality control (QC) and analytical method development (e.g., HPLC, LC-MS).
• Biochemical Research: Investigated for its interaction with tubulin and other biological targets relevant to inflammation and pain pathways.

Basic Information

Product Name	n-Desacetyl-n-Formyl Thiocolchicoside
CAS No.	219547-29-2
Molecular Formula	C28H33NO9S
Molecular Weight	559.63 g/mol
Synonyms	N-Desacetyl-N-formylthiocolchicoside; 3-Demethylthiocolchicine N-formyl derivative; Thiocolchicoside N-formyl analog; 2-(Formylmethyl)-10-methoxy-1,2,3,9-tetramethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-6-one; N-Formyl-N-desacetylthiocolchicoside; Desacetyl Formyl Thiocolchicoside
EINECS	Contact for details

Quality Control

Our n-Desacetyl-n-Formyl Thiocolchicoside is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.