Description

3-Fluoro-4-Nitrobenzonitrile is a versatile fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its molecular structure, featuring both an electron-withdrawing nitro group and a fluorine atom ortho to the nitrile, makes it a critical intermediate for constructing complex molecules with tailored electronic properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its polarizable nitrile group and fluorine substitution.
• Chemical Biology Probes: Employed in the design and synthesis of fluorescent tags, photoaffinity labels, and other molecular probes for biological target identification.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination, enabling rapid diversification of chemical libraries.

Basic Information

Product Name	3-Fluoro-4-Nitrobenzonitrile
CAS No.	218632-01-0
Molecular Formula	C7H3FN2O2
Molecular Weight	166.11 g/mol
Synonyms	4-Nitro-3-fluorobenzonitrile; 3-Fluoro-4-nitrobenzenecarbonitrile; Benzonitrile, 3-fluoro-4-nitro-; 3-Fluoro-4-cyanomitrobenzene; 2-Fluoro-4-cyanomitrobenzene; 3-Fluoro-4-nitro-phenyl cyanide; 3-Fluoro-4-nitrobenzonitrile (technical grade)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet your project's specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.