Description

2-Amino-2-(3,4-Difluorophenyl)Acetonitrile is a high-value, multi-functional chemical intermediate featuring a reactive nitrile group and a primary amine on a difluorinated aromatic scaffold. This compound matters for its versatility in synthesizing complex molecules, particularly in the pharmaceutical sector where the 3,4-difluorophenyl moiety is a privileged structure. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material industries for constructing active pharmaceutical ingredients (APIs) and other specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides that leverage the difluorophenyl group for enhanced bioactivity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services for clients in life sciences.
• Academic and Industrial R&D: Used in research laboratories for methodological studies and exploring new chemical spaces.

Basic Information

Product Name	2-Amino-2-(3,4-Difluorophenyl)Acetonitrile
CAS No.	218449-30-0
Molecular Formula	C8H6F2N2
Molecular Weight	168.14 g/mol
Synonyms	(3,4-Difluorophenyl)glycinonitrile; 2-Amino-2-(3,4-difluorophenyl)ethanenitrile; α-Amino-3,4-difluorobenzeneacetonitrile; 3,4-Difluoro-α-aminophenylacetonitrile; 2-(3,4-Difluorophenyl)-2-aminoacetonitrile; Glycine, 2-(3,4-difluorophenyl)-, nitrile; Amino(3,4-difluorophenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 2-Amino-2-(3,4-Difluorophenyl)Acetonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.