Description

5-(1,3-Dioxan-2-Yl)-2-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block with a protected aldehyde functionality. This compound is valued for its role as a versatile synthetic intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought by research and development chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine atom and nitrile group can enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced organic electronic materials and liquid crystals due to its aromatic and polarizable structure.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.
• Academic and Industrial R&D: Utilized in exploratory chemistry for method development and creating libraries of novel fluorinated compounds for screening.

Basic Information

Product Name	5-(1,3-Dioxan-2-Yl)-2-Fluorobenzonitrile
CAS No.	218301-23-6
Molecular Formula	C11H10FNO2
Molecular Weight	207.20 g/mol
Synonyms	2-Fluoro-5-(1,3-dioxan-2-yl)benzonitrile; 2-Fluoro-5-(2,4,6-trioxa-1-borabicyclo[3.1.0]hex-1-yl)benzonitrile (alternative representation); Benzonitrile, 2-fluoro-5-(1,3-dioxan-2-yl)-; 5-(1,3-Dioxan-2-yl)-2-fluorobenzonitrile; 218301-23-6; 2-Fluoro-5-(1,3-dioxanyl)benzonitrile; Fluorobenzonitrile-dioxane derivative
EINECS	Contact for details

Quality Control

Our 5-(1,3-Dioxan-2-Yl)-2-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.