Description

2-Cyano-4-Fluorobenzyl Bromide is a versatile and high-value halogenated aromatic building block essential for advanced organic synthesis. Its molecular structure, featuring both a reactive benzyl bromide and a cyano group on a fluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic and functional group diversity.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Cyano-4-Fluorobenzyl Bromide
CAS No.	217661-27-3
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	4-Fluoro-2-cyanobenzyl Bromide; (4-Fluoro-2-cyanophenyl)methyl Bromide; 2-Cyano-4-fluorobenzyl Bromide; α-Bromo-4-fluoro-2-cyanotoluene; 4-Fluoro-2-(bromomethyl)benzonitrile; 2-(Bromomethyl)-4-fluorobenzonitrile; Bromomethyl-4-fluoro-2-cyanobenzene
EINECS	Contact for details

Quality Control

Our 2-Cyano-4-Fluorobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.