Description

R-(+)-Bisoprolol Fumarate is the pharmacologically active enantiomer of the β-1 selective adrenergic receptor blocker, bisoprolol. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure cardiovascular pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories and API manufacturers focused on producing advanced cardioselective β-blocker therapies with optimized efficacy and reduced side-effect profiles.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the production of enantiopure bisoprolol fumarate and related β-blocker drugs.
• Pharmaceutical Research & Development: Used in preclinical and clinical studies to investigate the specific pharmacological profile of the R-enantiomer.
• Process Chemistry & Scale-Up: Serves as a reference standard and starting material for developing and optimizing asymmetric synthesis routes.
• Analytical Standard: Employed as a high-purity standard for HPLC, chiral chromatography, and spectroscopic methods to ensure quality control of final drug products.
• Formulation Development: Used in stability studies and formulation trials for new drug delivery systems targeting hypertension and angina.

Basic Information

Product Name	R-(+)-Bisoprolol Fumarate
CAS No.	216309-92-1
Molecular Formula	C22H35NO8
Molecular Weight	441.52 g/mol
Synonyms	(R)-(+)-Bisoprolol Fumarate; (R)-Bisoprolol Fumarate; (+)-Bisoprolol Fumarate; Bisoprolol Fumarate R-enantiomer; 1-(4-((2R)-2-Hydroxy-3-(isopropylamino)propoxy)phenyl)-3-isopropylaminopropan-2-ol Fumarate; UNII-6O7V5S5W6U; (R)-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol (E)-2-butenedioate
EINECS	Contact for details

Quality Control

Our R-(+)-Bisoprolol Fumarate is manufactured under strict quality management systems. Each batch is tested to ensure compliance with stringent specifications for identity, purity, and enantiomeric excess, suitable for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.