Description

α,α-Difluoro-4-Methyl-Benzeneacetonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its core value lies in the strategic introduction of difluoromethylene and cyano groups into molecular frameworks, enabling the fine-tuning of physicochemical properties such as metabolic stability and lipophilicity. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in drug discovery and crop protection agent development.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro group can enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved performance and durability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with unique dielectric, thermal, and surface properties.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation reactions and fluorinated compound libraries.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments that offer enhanced light fastness and color properties.

Basic Information

Product Name	α,α-Difluoro-4-Methyl-Benzeneacetonitrile
CAS No.	215859-26-0
Molecular Formula	C9H7F2N
Molecular Weight	167.16 g/mol
Synonyms	2,2-Difluoro-2-(4-methylphenyl)acetonitrile; (4-Methylphenyl)difluoroacetonitrile; p-Tolyldifluoroacetonitrile; 4-Methyl-α,α-difluorobenzeneacetonitrile; α,α-Difluoro-p-toluyl cyanide; 2-(4-Methylphenyl)-2,2-difluoroacetonitrile; Difluoro(4-methylphenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our α,α-Difluoro-4-Methyl-Benzeneacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and lot-to-lot consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.