Description

Degarelix is a synthetic decapeptide antagonist of gonadotropin-releasing hormone (GnRH) receptors. This compound is a critical active pharmaceutical ingredient (API) used in advanced hormonal therapy. It is primarily required by pharmaceutical manufacturers and research institutions developing treatments for hormone-sensitive conditions, particularly in oncology and endocrinology.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for the treatment of advanced hormone-dependent prostate cancer.
• Clinical Research: Utilized in preclinical and clinical studies investigating new therapeutic protocols for endocrine disorders.
• Drug Development: Serves as a reference standard and key intermediate in the R&D of novel GnRH antagonist-based therapies.
• Specialty Formulations: Used in the development of controlled-release depot injections for sustained hormonal suppression.

Basic Information

Product Name	Degarelix
CAS No.	214766-78-6
Molecular Formula	C82H103ClN18O16
Molecular Weight	1632.7 g/mol
Synonyms	Degarelix Acetate; FE 200486; Azaline B; GnRH Antagonist FE200486; Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(L-hydroorotyl)-D-4Aph(Chm)-Leu-Lys(iPr)-Pro-D-Ala-NH2 acetate; 1-[4-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-Acetamido-3-(2-naphthyl)propanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-(3-pyridyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-aminophenyl)propanoyl]amino]-3-(4-[[(2S)-2,6-diaminohexanoyl]amino]phenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-[(diaminomethylidene)amino]pentanoyl]amino]-1-oxopropan-2-yl]azanium acetate
EINECS	Contact for details

Quality Control

Our Degarelix is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters are provided to guarantee supply chain integrity and product consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its hygroscopic nature, the product must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.