Description

Benzonitrile, 4-Acetyl-2-Fluoro- (9Ci) CAS NO 214760-18-6 is a specialized fluorinated aromatic nitrile derivative, serving as a high-value pharmaceutical intermediate and organic synthesis building block. Its molecular structure, featuring both acetyl and fluorine substituents on the benzonitrile core, makes it a critical precursor for constructing complex molecules in medicinal chemistry. This compound is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and advanced material science sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers where fluorinated aromatic units are required.
• Chemical Biology Probes: Utilized as a scaffold for developing fluorescent tags and molecular probes for imaging and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	Benzonitrile, 4-Acetyl-2-Fluoro- (9Ci)
CAS No.	214760-18-6
Molecular Formula	C9H6FNO
Molecular Weight	163.15 g/mol
Synonyms	4-Acetyl-2-fluorobenzonitrile; 2-Fluoro-4-acetylbenzonitrile; 1-(4-Cyano-3-fluorophenyl)ethan-1-one; 4-Cyano-3-fluoroacetophenone; 2-Fluoro-4-cyanobenzophenone; 4-Acetyl-2-fluorophenyl cyanide; (4-Cyano-3-fluorophenyl)methyl ketone; Ethanone, 1-(4-cyano-3-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Acetyl-2-Fluoro- (9Ci) is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance as a synthesis intermediate. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable for pharmaceutical use, and we support customer audits and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.