Description

2-Fluoro-4-(2-Hydroxypropan-2-Yl)Benzonitrile is a versatile fluorinated aromatic nitrile building block, prized for its unique molecular architecture that combines a benzonitrile core with fluorine and a tertiary alcohol group. This compound is critical for driving innovation in advanced material science and pharmaceutical research, enabling the synthesis of complex molecules with tailored properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a precursor for developing fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce polar nitrile and hydroxyl functional groups into polymer chains, altering thermal and mechanical properties.
• Cross-Coupling Reactions: The nitrile and halogen groups make it a suitable substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig couplings.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	2-Fluoro-4-(2-Hydroxypropan-2-Yl)Benzonitrile
CAS No.	214760-17-5
Molecular Formula	C10H10FNO
Molecular Weight	179.19 g/mol
Synonyms	4-(2-Hydroxypropan-2-yl)-2-fluorobenzonitrile; 2-Fluoro-4-(2-hydroxy-2-propyl)benzonitrile; 2-Fluoro-4-(2-hydroxyisopropyl)benzonitrile; 2-Fluoro-4-(α-hydroxyisopropyl)benzonitrile; 4-(1-Hydroxy-1-methylethyl)-2-fluorobenzonitrile; Benzonitrile, 2-fluoro-4-(2-hydroxy-2-propyl)-; 214760-17-5 (CAS Registry)
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-(2-Hydroxypropan-2-Yl)Benzonitrile is manufactured under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles is available for each lot upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.