Description

Metoprolol Succinate is a selective β-1 adrenergic receptor blocker, chemically formulated as the succinate salt of metoprolol. This active pharmaceutical ingredient (API) is critical for the formulation of extended-release oral dosage forms, providing consistent 24-hour therapeutic plasma levels for improved patient compliance. It is essential for pharmaceutical manufacturers and R&D facilities developing cardiovascular medications, primarily for the management of hypertension, angina pectoris, and heart failure.

Application

• Pharmaceutical API: Primary use as the active ingredient in extended-release (ER/XL) tablet formulations for cardiovascular therapy.
• Hypertension Treatment: Formulation of medications for the long-term control of high blood pressure.
• Angina Pectoris Management: Used in drugs that prevent chest pain caused by reduced blood flow to the heart.
• Heart Failure Therapy: A key component in treatment regimens for stable, symptomatic chronic heart failure.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded metoprolol succinate medications.
• Clinical Research: Serves as a reference standard and raw material in pharmacokinetic and pharmacodynamic studies.
• Drug Development: Used in pre-formulation studies and the development of novel controlled-release drug delivery systems.

Basic Information

Product Name	Metoprolol Succinate
CAS No.	207983-04-8
Molecular Formula	C34H56N2O8
Molecular Weight	620.82 g/mol
Synonyms	Metoprolol Succinate Salt; Metoprolol Hydrogen Succinate; (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol Succinate; Metoprolol Acid Succinate; Betaloc ZOK; Toprol-XL; Lopressor Succinate; Seloken ZOC
EINECS	Contact for details

Quality Control

Our Metoprolol Succinate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, with specifications typically aligned with major pharmacopoeias. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for identity, assay, purity, and related substances. We support compliance with cGMP, ICH Q7, and relevant FDA guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.