Description

3-(Difluoromethoxy)-1,2-Difluoro-4-Nitro-Benzene is a high-purity fluorinated aromatic nitro compound, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique difluoromethoxy and difluoro substitution pattern makes it a valuable building block for introducing specific fluorine motifs into target molecules, enhancing their physicochemical properties. This compound is primarily required by R&D and production teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and electronic materials that benefit from fluorinated aromatic units.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to create complex, fluorinated molecular architectures.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	3-(Difluoromethoxy)-1,2-Difluoro-4-Nitro-Benzene
CAS No.	206546-18-1
Molecular Formula	C7H3F4NO3
Molecular Weight	225.10 g/mol
Synonyms	1,2-Difluoro-3-(difluoromethoxy)-4-nitrobenzene; 4-Nitro-1,2-difluoro-3-(difluoromethoxy)benzene; Benzene, 1,2-difluoro-3-(difluoromethoxy)-4-nitro-; 3-(Difluoromethoxy)-1,2-difluoro-4-nitrobenzene; 206546-18-1; DFMDFNB
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethoxy)-1,2-Difluoro-4-Nitro-Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.