Description

3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-Carbazol-4-Yloxy)-2-Hydroxypropyl]Amino]-2-Methylpropyl]Phenoxy]- is a high-purity, complex organic compound of significant interest in advanced pharmaceutical research and development. This molecule is valued for its sophisticated structure, which serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents. It is primarily targeted towards research institutions and pharmaceutical companies engaged in the discovery of new drugs, particularly in areas requiring specialized receptor targeting.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel drug candidates, particularly for central nervous system (CNS) or cardiovascular targets.
• Active Pharmaceutical Ingredient (API) Research: Used directly in preclinical and clinical research as a potential API due to its specific carbazole and pyridine pharmacophores.
• Biochemical Research: Employed as a reference standard or probe in biochemical assays to study enzyme inhibition, receptor binding affinity, and signal transduction pathways.
• Medicinal Chemistry: Provides a versatile scaffold for structure-activity relationship (SAR) studies, enabling the optimization of potency, selectivity, and pharmacokinetic properties.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	3-Pyridinecarboxamide, 6-[4-[2-[[(2S)-3-(9H-Carbazol-4-Yloxy)-2-Hydroxypropyl]Amino]-2-Methylpropyl]Phenoxy]-
CAS No.	204592-94-9
Molecular Formula	C31H32N4O4
Molecular Weight	524.61 g/mol
Synonyms	6-[4-[2-[[(2S)-3-(9H-Carbazol-4-Yloxy)-2-Hydroxypropyl]Amino]-2-Methylpropyl]Phenoxy]-3-Pyridinecarboxamide; (S)-6-(4-(2-((3-(9H-Carbazol-4-yloxy)-2-Hydroxypropyl)Amino)-2-Methylpropyl)Phenoxy)Nicotinamide; Carvedilol Impurity; Carvedilol Related Compound; UNII-9I0BDR9H5F; 9I0BDR9H5F; Carvedilol Metabolite (potential); BM 910228 (research code)
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC purity analysis, chiral purity verification, and identification by spectroscopic methods (IR, NMR, MS). We support regulatory submissions by providing detailed Certificates of Analysis (COA) with full traceability. Specifications are aligned with ICH guidelines, and custom synthesis can be performed under current Good Manufacturing Practice (cGMP) conditions for clinical supply.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is light-sensitive (store away from light); prolonged exposure to light or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.