Description

2-Fluoro-4-(Piperazin-1-Yl)Benzonitrile is a high-value, fluorinated aromatic nitrile building block featuring a piperazine moiety. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel, targeted small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncological targets.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its versatile piperazine and nitrile functional groups.
• Chemical Biology Probes: Serves as a precursor for synthesizing fluorescent or affinity-based probes to study biological pathways.
• Agrochemical Development: Potential intermediate in the research and synthesis of new crop protection agents and herbicides.
• Material Science Research: Investigated as a monomer or additive for specialty polymers with specific electronic or optical properties.

Basic Information

Product Name	2-Fluoro-4-(Piperazin-1-Yl)Benzonitrile
CAS No.	204192-45-0
Molecular Formula	C11H12FN3
Molecular Weight	205.23 g/mol
Synonyms	4-(Piperazin-1-yl)-2-fluorobenzonitrile; 2-Fluoro-4-(1-piperazinyl)benzonitrile; 2-Fluoro-4-piperazin-1-ylbenzonitrile; 2-Fluoro-4-piperazinobenzonitrile; Benzonitrile, 2-fluoro-4-(1-piperazinyl)-; 204192-45-0; 2-Fluoro-4-(piperazin-1-yl)benzonitrile; 2-Fluoro-4-piperazin-1-yl-benzonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-(Piperazin-1-Yl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.