Description

Brostallicin is a synthetic, minor groove-binding DNA alkylator belonging to the cyclopropylpyrroloindole (CPI) class of antitumor agents. This compound is significant for its unique mechanism of action, which involves sequence-selective DNA alkylation, and its activity against various cancer cell lines, including those resistant to other chemotherapeutic agents. It is primarily of interest to researchers and pharmaceutical developers in the fields of oncology drug discovery and preclinical development for investigating novel cancer therapies. Brostallicin CAS NO 203258-60-0 represents a valuable tool compound for biochemical and pharmacological studies.

Application

• Oncology Research & Drug Discovery: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical studies for evaluating antitumor efficacy and mechanism of action.
• Biochemical Research: Used in vitro to study DNA minor groove interactions, alkylation processes, and the induction of apoptosis in cancer cells.
• Pharmacology Studies: Employed in animal models to investigate pharmacokinetics, biodistribution, and the therapeutic window of CPI-class compounds.
• Mechanism of Action Analysis: A critical tool for understanding and overcoming multidrug resistance (MDR) in cancer due to its distinct biological pathway.
• Pharmaceutical Development: Used in the formulation development and stability testing of potential injectable chemotherapeutic agents.
• Academic Research: Utilized in university and institutional labs for fundamental cancer biology and medicinal chemistry research projects.

Basic Information

Product Name	Brostallicin
CAS No.	203258-60-0
Molecular Formula	C₂₈H₂₈N₄O₆
Molecular Weight	516.55 g/mol
Synonyms	PNU-166196; Brostallicin; (1S,2R)-1-(2-{[(2S)-2-{[(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]amino}-3-methylbutanoyl]amino}ethyl)-N⁵-[(1R)-1-{[(2S)-2-{[(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanoyl]amino}-3-methylbutanoyl]amino}ethyl]-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-5,7-dicarboxamide; Fmoc-Brostallicin analog
EINECS	Contact for details

Quality Control

Our Brostallicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identity confirmation by spectroscopic methods (IR, NMR, MS), and stringent control of residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications. We support cGMP standards for advanced pharmaceutical development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay (HPLC)	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.