Description

3-Chloro-4-Nitrobenzodifluoride is a high-value fluorinated aromatic intermediate, distinguished by its unique combination of chloro, nitro, and difluoromethyl substituents. This compound is critical for synthesizing advanced molecules where the introduction of fluorine atoms is required to modulate biological activity, chemical stability, and material properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where fluorine incorporation enhances efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals that require fluorinated aromatic units for improved performance.
• Organic Synthesis: A versatile reagent for introducing the 3-chloro-4-nitrodifluoromethylbenzene moiety into more complex molecular architectures via cross-coupling and substitution reactions.
• Dye and Pigment Intermediate: Employed in the production of specialized fluorinated colorants with unique light-fastness and chemical resistance properties.

Basic Information

Product Name	3-Chloro-4-Nitrobenzodifluoride
CAS No.	202752-31-6
Molecular Formula	C7H4ClF2NO2
Molecular Weight	207.56 g/mol
Synonyms	1-Chloro-2-nitro-4-(difluoromethyl)benzene; 3-Chloro-4-nitro-α,α-difluorotoluene; 4-Nitro-3-chlorobenzylidene fluoride; 2-Nitro-5-chlorobenzotrifluoride (related isomer); 3-Chloro-4-nitrobenzyl difluoride; Benzene, 1-chloro-2-nitro-4-(difluoromethyl)-; (3-Chloro-4-nitrophenyl)difluoromethane
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Nitrobenzodifluoride is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring traceability and compliance with your project specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.