Description

Bis(2-Methoxyethyl)Aminosulfur Trifluoride is a specialized fluorinating agent of significant importance in advanced synthetic chemistry. Its primary value lies in its ability to efficiently convert alcohols and carbonyl groups to the corresponding alkyl and difluoromethylene compounds, respectively, which is a critical transformation in pharmaceutical and agrochemical development. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require reliable and high-purity building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the selective introduction of fluorine atoms into drug candidates, enhancing metabolic stability and bioavailability.
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides, pesticides, and fungicides where fluorinated motifs improve activity and environmental persistence.
• Material Science Research: Employed in the development of novel fluorinated polymers, liquid crystals, and electronic materials with unique properties.
• Deoxofluorination Reactions: Specifically effective for converting aldehydes and ketones to gem-difluoro compounds, a valuable transformation in medicinal chemistry.
• Nucleoside & Carbohydrate Chemistry: Facilitates the synthesis of fluorinated sugar analogs and modified nucleosides for antiviral and anticancer applications.
• Process Chemistry & Scale-up: Suitable for use in kilo-lab and pilot plant operations for the production of fluorinated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Bis(2-Methoxyethyl)Aminosulfur Trifluoride
CAS No.	202289-38-1
Molecular Formula	C6H14F3NO2S
Molecular Weight	221.24 g/mol
Synonyms	Deoxo-Fluor; Bis(2-methoxyethyl)aminosulfur trifluoride; 2-Methoxy-N,N-bis(2-methoxyethyl)-1,1,1-trifluoro-λ4-sulfanamine; BMAST; XtalFluor-E® (related commercial name); DAST analog; (Bis(2-methoxyethyl)amino)sulfur trifluoride; N,N-Bis(2-methoxyethyl)sulfur trifluoride amine
EINECS	Contact for details

Quality Control

Our Bis(2-Methoxyethyl)Aminosulfur Trifluoride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (HPLC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.