Description

1-(Difluoromethyl)-4-Nitrobenzene is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a difluoromethyl and a nitro group, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those requiring the incorporation of fluorine atoms to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoromethyl group can enhance biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitutions, and reduction reactions to create diverse libraries of fluorinated compounds for screening.

Basic Information

Product Name	1-(Difluoromethyl)-4-Nitrobenzene
CAS No.	29848-57-5
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	4-Nitrobenzylidene Difluoride; α,α-Difluoro-4-nitro toluene; p-Nitro-α,α-difluorotoluene; 4-Nitro-α,α-difluorotoluene; 1-(Difluoromethyl)-4-nitrobenzene; (Difluoromethyl)benzene, 4-nitro-; p-(Difluoromethyl)nitrobenzene
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)-4-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.