Description

1-(4-(Trifluoromethyl)Phenyl)Cyclobutanecarbonitrile is a versatile and high-value organic intermediate featuring a cyclobutane ring and a trifluoromethylphenyl group. This compound is prized for its unique structural motif, which imparts desirable physicochemical properties for advanced material and pharmaceutical synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical starting material for synthesizing advanced organic electronic materials used in displays and lighting.
• Organic Synthesis Scaffold: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis due to its rigid cyclobutane core.
• Fluorine Chemistry Research: An important compound for investigating the effects of fluorine substitution on molecular properties in academic and industrial R&D settings.

Basic Information

Product Name	1-(4-(Trifluoromethyl)Phenyl)Cyclobutanecarbonitrile
CAS No.	29786-44-5
Molecular Formula	C12H10F3N
Molecular Weight	225.21 g/mol
Synonyms	1-[4-(Trifluoromethyl)phenyl]cyclobutanecarbonitrile; 4-(1-Cyanocyclobutyl)benzotrifluoride; α-(4-Trifluoromethylphenyl)cyclobutanecarbonitrile; Cyclobutanecarbonitrile, 1-[4-(trifluoromethyl)phenyl]-; 1-(p-Trifluoromethylphenyl)cyclobutanecarbonitrile; 1-(4-Trifluoromethylphenyl)cyclobutanenitrile; 4-(Cyclobutanecarbonitrile-1-yl)benzotrifluoride
EINECS	Contact for details

Quality Control

Our production of 1-(4-(Trifluoromethyl)Phenyl)Cyclobutanecarbonitrile adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot is fully characterized using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.