Description

9-Fluoro-11Beta,16Alpha,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione Mono(Hydrogen Succinate) is a high-purity synthetic corticosteroid derivative, specifically a succinate ester prodrug of a fluorinated glucocorticoid. This compound is of significant value in pharmaceutical research and development due to its potent anti-inflammatory and immunosuppressive properties. It is primarily required by advanced pharmaceutical manufacturers and research institutions for the development of novel topical and injectable steroid formulations. The product is supplied under stringent quality control to ensure batch-to-batch consistency for critical applications.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the manufacturing of potent topical corticosteroid medications.
• Pharmaceutical Research: Used in preclinical and clinical studies to investigate mechanisms of glucocorticoid receptor activity and metabolic pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Prodrug Development: Utilized in research focused on enhancing the solubility, bioavailability, and delivery of corticosteroid therapies.
• Dermatological Formulations: Investigated for use in creams, ointments, and lotions targeting severe inflammatory skin conditions.
• Veterinary Medicine: Potential application in developing anti-inflammatory treatments for companion and livestock animals.

Basic Information

Product Name	9-Fluoro-11Beta,16Alpha,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione Mono(Hydrogen Succinate)
CAS No.	29593-56-4
Molecular Formula	C25H31FO8
Molecular Weight	478.51 g/mol
Synonyms	Fluocinolone Acetonide 21-Acetate Succinate; Fluocinolone Acetonide Hydrogen Succinate; 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-(hydrogen succinate); Fluocinolone Acetonide 21-Hemisuccinate; 21-Succinyloxy-9α-fluoro-11β,16α,17-trihydroxypregna-1,4-diene-3,20-dione; Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,16α,17,21-tetrahydroxy-, mono(1,4-butanedioate)
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,16Alpha,17,21-Tetrahydroxypregna-1,4-Diene-3,20-Dione Mono(Hydrogen Succinate) is manufactured under a quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.