Description

6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate is a high-purity synthetic corticosteroid intermediate of significant commercial and pharmaceutical importance. This compound serves as a critical precursor in the synthesis of potent anti-inflammatory and immunosuppressive steroid APIs, enabling the development of advanced therapeutic formulations. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in steroid hormone production.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of advanced corticosteroid active pharmaceutical ingredients (APIs).
• Anti-inflammatory Drug Development: Used in research and production of potent glucocorticoid receptor agonists for treating inflammatory and autoimmune conditions.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for steroid-based therapeutics.
• Biochemical Research: Utilized in studies investigating steroid hormone action, receptor binding, and metabolic pathways.

Basic Information

Product Name	6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate
CAS No.	29205-06-9
Molecular Formula	C₂₇H₃₇FO₆
Molecular Weight	476.58 g/mol
Synonyms	Flumethasone Pivalate; Flumethasone 21-Pivalate; 6α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-pivalate; 6α-Fluoro-16α-methylprednisolone 21-pivalate; Flumetasone Pivalate; NSC 107680; SQ 15102; Flumethasone 21-Trimethylacetate
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Pivalate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with cGMP and ICH Q3 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.