Description

Adriamycin is a potent anthracycline antibiotic and antineoplastic agent, widely recognized for its critical role in oncology. Its primary value lies in its ability to intercalate with DNA and inhibit topoisomerase II, making it a cornerstone chemotherapeutic drug for treating various cancers. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers, research institutions, and compounding facilities developing injectable formulations and conducting clinical or preclinical studies.

Application

• Oncological Therapeutics: A key component in chemotherapeutic regimens for treating breast cancer, ovarian cancer, bladder cancer, acute leukemias, and soft tissue sarcomas.
• Pharmaceutical Formulation: Serves as the active pharmaceutical ingredient (API) in the manufacture of sterile injectable solutions and lyophilized powders for intravenous administration.
• Clinical & Preclinical Research: Used in laboratory studies to investigate cancer biology, mechanisms of drug resistance, and the efficacy of novel combination therapies.
• Drug Discovery & Development: Employed as a reference standard or a building block in the synthesis of new anthracycline derivatives and targeted drug conjugates.
• Biochemical Research: Utilized as a tool compound to study DNA interaction, apoptosis induction, and free radical generation in cellular models.

Basic Information

Product Name	Adriamycin
CAS No.	29042-30-6
Molecular Formula	C27H29NO11
Molecular Weight	543.52 g/mol
Synonyms	Doxorubicin; Doxorubicin Hydrochloride; 14-Hydroxydaunomycin; Hydroxydaunorubicin; NSC-123127; FI-106; ADM; DXR
EINECS	249-363-7

Quality Control

Our Adriamycin is manufactured and tested under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical use. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant pharmacopeial guidelines (such as USP/EP) and support our customers with full traceability and regulatory documentation for their drug master files (DMFs).

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) as specified. Due to its hygroscopic nature, the container must be kept in a dry environment. For long-term storage, consider under an inert atmosphere to minimize oxidative degradation.

Specification

Item	Specification
Appearance	Orange-red, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	[α]20/D: +248° to +258° (c=0.1 in methanol)
Bacterial Endotoxins	< 5.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.