Description

Trifluoroacetyl-Menthol CAS NO 28587-50-0 is a high-purity, specialty fluorinated derivative of menthol, designed for advanced chemical synthesis. This compound is valued for its ability to introduce the trifluoroacetyl group, a key moiety for modifying the physicochemical properties of target molecules, enhancing their lipophilicity and metabolic stability. It serves as a critical chiral building block and intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and fragrance industries seeking to develop novel compounds with optimized performance.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs to improve drug bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoroacetyl group can enhance biological activity and environmental stability.
• Flavor & Fragrance Ingredient: Acts as a precursor for synthesizing novel, high-value aroma chemicals with unique organoleptic properties derived from the menthol backbone.
• Organic Synthesis Reagent: Employed in academic and industrial R&D labs as a versatile fluorinating and protecting group agent in complex multi-step synthetic routes.
• Material Science Research: Utilized in the synthesis of specialty monomers or additives for advanced polymers, where fluorine incorporation can alter surface energy and material properties.

Basic Information

Product Name	Trifluoroacetyl-Menthol
CAS No.	28587-50-0
Molecular Formula	C13H19F3O2
Molecular Weight	264.29 g/mol
Synonyms	(-)-Menthyl trifluoroacetate; L-Menthyl trifluoroacetate; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 2,2,2-trifluoroacetate; Trifluoroacetic acid (-)-menthyl ester; Menthol trifluoroacetate; 2,2,2-Trifluoroacetic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester; (1R,2S,5R)-Menthyl trifluoroacetate
EINECS	Contact for details

Quality Control

Our Trifluoroacetyl-Menthol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral GC for enantiomeric excess, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which could compromise product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (GC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.