Description

(6A,11B,16A,17A)-6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxoandrosta-1,4-Diene-17-Carboxylic Acid Methyl Ester is a high-purity synthetic steroid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its precise molecular structure, which is engineered for targeted biological activity and serves as a key building block in complex synthesis pathways. This compound is essential for research and development laboratories and production facilities in the pharmaceutical and biotechnology sectors, particularly for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent corticosteroid and anti-inflammatory drug candidates.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new steroid-based therapies.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in multi-step synthetic routes to manufacture complex steroid APIs with enhanced potency and selectivity.
• Biochemical Research: Serves as a tool compound for studying steroid hormone receptor interactions and metabolic pathways.
• Process Development: Used in scaling up and optimizing manufacturing processes for steroid-derived pharmaceuticals.

Basic Information

Product Name	(6A,11B,16A,17A)-6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxoandrosta-1,4-Diene-17-Carboxylic Acid Methyl Ester
CAS No.	28416-84-4
Molecular Formula	C₂₂H₂₆F₂O₆
Molecular Weight	424.44 g/mol
Synonyms	6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid methyl ester; Difluoromethylprednisolone methyl ester; 6α,9α-Difluoro-16α-methylprednisolone 17β-methyl ester; 6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid methyl ester; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-methyl ester derivative; 16α-Methyl-6α,9α-difluoroprednisolone 17β-methyl ester; Methyl 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylate
EINECS	Contact for details

Quality Control

Our (6A,11B,16A,17A)-6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxoandrosta-1,4-Diene-17-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications suitable for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.