Description

(6A,11B,16A,17A)-6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxoandrosta-1,4-Diene-17-Carboxylic Acid is a high-purity, fluorinated steroid derivative with significant synthetic utility. This compound serves as a critical advanced intermediate in the pharmaceutical development of potent glucocorticoid receptor agonists. It is primarily sought by research institutions and manufacturers engaged in the synthesis of novel anti-inflammatory and immunosuppressive therapeutic agents. The precise structural modifications, including the difluoro and carboxylic acid groups, make it a valuable building block for creating molecules with enhanced metabolic stability and receptor binding affinity.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel corticosteroid drugs and glucocorticoid receptor modulators.
• Research & Development: Used in medicinal chemistry programs to explore structure-activity relationships (SAR) for anti-inflammatory targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in the production route for specific, high-potency steroid-based APIs.
• Biochemical Research: Serves as a tool compound for studying steroid hormone receptor interactions and signaling pathways in vitro.
• Process Chemistry: Utilized for scaling up and optimizing synthetic routes to complex steroid molecules under GMP-like conditions.

Basic Information

Item	Details
Product Name	(6A,11B,16A,17A)-6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxoandrosta-1,4-Diene-17-Carboxylic Acid
CAS No.	28416-82-2
Molecular Formula	C21H24F2O5
Molecular Weight	394.41 g/mol
Synonyms	6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carboxylic acid; Difluorocortienic Acid; 6,9-Difluoro-δ1,4-cortienic acid; 17β-Carboxy-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-androsta-1,4-dien-3-one; 6α,9α-Difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-(carboxy)androsta-1,4-diene-17β-carboxylic acid; Cortienic acid, 6,9-difluoro-; A fluorinated steroid intermediate
EINECS	Contact for details

Quality Control

Our (6A,11B,16A,17A)-6,9-Difluoro-11,17-Dihydroxy-16-Methyl-3-Oxoandrosta-1,4-Diene-17-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development with material suitable for use under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.