Description

(S)-Penbutolol Hydrochloride is a high-purity enantiomer of the non-selective β-adrenergic blocking agent, penbutolol. This compound is of significant value in pharmaceutical research and development, particularly for studying stereospecific drug-receptor interactions and metabolic pathways. It serves as a critical chiral intermediate and reference standard for analytical method development and quality control in the production of cardiovascular active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of penbutolol-based drug products in HPLC, GC, and spectroscopic analyses.
• Chiral Intermediate: Serves as a key building block in the enantioselective synthesis of advanced β-blocker compounds for cardiovascular research.
• Metabolic and Pharmacokinetic Studies: Employed in in vitro and in vivo studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of the (S)-enantiomer.
• Analytical Method Development: Essential for developing and validating chiral separation methods in quality control laboratories.
• Biochemical Research: Used as a tool compound to study β-adrenergic receptor binding affinity and selectivity.

Basic Information

Product Name	(S)-Penbutolol Hydrochloride
CAS No.	28291-30-7
Molecular Formula	C18H30ClNO3
Molecular Weight	343.89 g/mol
Synonyms	(S)-1-(tert-Butylamino)-3-(2-cyclopentylphenoxy)-2-propanol Hydrochloride; (S)-Penbutolol HCl; (-)-Penbutolol Hydrochloride; Levopenbutolol Hydrochloride; (S)-(-)-1-(tert-Butylamino)-3-(o-cyclopentylphenoxy)-2-propanol Hydrochloride; HOE 893d; (2S)-1-(1,1-Dimethylethyl)amino-3-(2-cyclopentylphenoxy)-2-propanol Hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Penbutolol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.