Description

Nicocortonide Acetate is a synthetic corticosteroid derivative with significant anti-inflammatory and immunosuppressive activity. This compound is a critical intermediate in the synthesis of advanced topical and systemic pharmaceutical formulations. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents for dermatological and inflammatory conditions. Our supply ensures high purity and batch-to-batch consistency for reliable research and production outcomes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Research & Development: Used in preclinical and clinical research for developing new anti-inflammatory and immunosuppressive drugs.
• Dermatological Formulations: Serves as a precursor for topical creams, ointments, and gels targeting psoriasis, eczema, and dermatitis.
• Steroid Prodrug Development: Utilized in creating prodrugs with enhanced bioavailability and targeted delivery profiles.
• Analytical Reference Standard: Provides a certified standard for quality control and regulatory testing in pharmaceutical laboratories.
• Veterinary Medicine: Investigated for use in anti-inflammatory treatments for animals.

Basic Information

Product Name	Nicocortonide Acetate
CAS No.	28202-60-0
Molecular Formula	C26H33NO7
Molecular Weight	471.55 g/mol
Synonyms	Nicocortonide 21-Acetate; 21-Acetoxyprednisolone 17-(Nicotinate); 11β,17α,21-Trihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate 17-(3-pyridinecarboxylate); Prednisolone 17-(Nicotinate) 21-Acetate; Nicocortonide Acetate Ester; 17α-(Pyridine-3-carbonyloxy)-11β,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our Nicocortonide Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.