Description

5,12-Naphthacenedione, 7,8,9,10-Tetrahydro-6,8,10,11-Tetrahydroxy-8-(1S)-1-Hydroxyethyl-1-Methoxy-, (8S,10S)- is a complex, stereochemically defined anthracycline derivative. This compound matters as a key synthetic intermediate or reference standard in advanced pharmaceutical research, particularly for the development of novel chemotherapeutic agents. It is needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology sectors working on next-generation oncology treatments.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of sophisticated anthracycline-based anticancer drugs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing to ensure batch consistency.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of DNA-intercalating agents and topoisomerase inhibitors.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of complex active pharmaceutical ingredients (APIs).
• Academic Research: A valuable compound for universities and research institutes exploring new mechanisms of action in medicinal chemistry.

Basic Information

Product Name	5,12-Naphthacenedione, 7,8,9,10-Tetrahydro-6,8,10,11-Tetrahydroxy-8-(1S)-1-Hydroxyethyl-1-Methoxy-, (8S,10S)-
CAS No.	28008-51-7
Molecular Formula	C21H24O9
Molecular Weight	420.41 g/mol
Synonyms	8(S)-Daunomycinone; 8(S)-Daunomycinone aglycone; (8S-cis)-8-Ethyl-8-hydroxy-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-naphthacenedione; 8(S)-Daunorubicinone; 8(S)-13-Dihydrodaunomycinone; Daunomycinone (8S isomer); 8S-Daunomycinone
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥95% (by HPLC), suitable for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Specifications can be aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.