Description

4-Chloro-2-Fluoro-5-Sulfonamidebenzonitrile is a high-purity, multi-functional aromatic intermediate of significant importance in advanced organic synthesis. Its unique molecular structure, featuring chloro, fluoro, sulfonamide, and nitrile functional groups, makes it a versatile and valuable building block for creating complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Synthesis: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the sulfonamide and fluorine substituents.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, substituted benzene core.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments where specific halogen and sulfonamide groups modify color and fastness properties.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-Sulfonamidebenzonitrile
CAS No.	27589-31-7
Molecular Formula	C7H4ClFN2O2S
Molecular Weight	234.63 g/mol
Synonyms	5-Cyano-2-chloro-4-fluorobenzenesulfonamide; 2-Chloro-4-fluoro-5-cyanobenzenesulfonamide; Benzenesulfonamide, 5-cyano-2-chloro-4-fluoro-; 4-Fluoro-2-chloro-5-sulfamoylbenzonitrile; 27589-31-7; 4-Chloro-2-fluoro-5-sulfamoylbenzonitrile; 2-Chloro-4-fluoro-5-sulfonamoylbenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Sulfonamidebenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for pharmaceutical and agrochemical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be hygroscopic; handle and store under dry conditions to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.