Description

Meprednisone Hemisuccinate is a synthetic corticosteroid ester prodrug, specifically the hemisuccinate salt of meprednisone. This compound is of significant value in pharmaceutical research and development as a key intermediate for the synthesis of potent anti-inflammatory and immunosuppressive agents. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of advanced steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) for corticosteroid medications.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new treatments for inflammatory conditions such as arthritis, asthma, and dermatitis.
• Immunosuppressive Therapy Development: Serves as a key compound in the research of drugs aimed at modulating immune responses, useful in autoimmune diseases and organ transplantation.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for the identification and assay of related steroid products.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor interactions and the metabolic pathways of synthetic steroids.
• Prodrug Formulation Studies: Investigated for its properties as a prodrug, where its hemisuccinate moiety can influence solubility, stability, and bioavailability.

Basic Information

Item	Details
Product Name	Meprednisone Hemisuccinate
CAS No.	27303-92-0
Molecular Formula	C₂₇H₃₆O₈
Molecular Weight	488.57 g/mol
Synonyms	Meprednisone 21-Hemisuccinate; 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione 21-Hemisuccinate; 21-(3-Carboxypropionyloxy)-17α-hydroxy-1,4-pregnadiene-3,11,20-trione; 1-Dehydro-17α-methylprednisolone 21-Hemisuccinate; 17α-Methylprednisolone 21-Hemisuccinate; 17α-Methyl-δ¹-prednisolone 21-Hemisuccinate; NSC-527579
EINECS	Contact for details

Quality Control

Our Meprednisone Hemisuccinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) documenting all test results are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.