Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-(Hydrogen Succinate) CAS NO 27297-42-3 is a high-purity synthetic corticosteroid derivative, specifically a succinate ester prodrug. This compound is a critical advanced pharmaceutical intermediate, valued for its potent anti-inflammatory and immunosuppressive properties. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of specialized injectable corticosteroid formulations.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Injectable Corticosteroid Prodrug: Used in the formulation of long-acting injectable anti-inflammatory medications, where the succinate ester enhances solubility and modifies release profiles.
• Research & Development: Serves as a reference standard and building block in medicinal chemistry for developing new glucocorticoid receptor agonists.
• Anti-inflammatory Agent Synthesis: Core component in manufacturing drugs for treating severe allergies, dermatological conditions, and autoimmune disorders.
• Veterinary Pharmaceuticals: Used in developing anti-inflammatory treatments for animals.

Basic Information

Item	Details
Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-(Hydrogen Succinate)
CAS No.	27297-42-3
Molecular Formula	C26H33FO8
Molecular Weight	492.54 g/mol
Synonyms	Methylprednisolone 21-Hemisuccinate; Methylprednisolone Hemisuccinate; U-67590A; 6α-Methylprednisolone 21-hemisuccinate; 11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-hemisuccinate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-hydrogen succinate; 6α-Methyl-δ1-hydrocortisone 21-hemisuccinate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-(Hydrogen Succinate) is manufactured under strict quality management systems. We offer material suitable for pharmaceutical R&D and GMP-grade applications, with specifications tailored to client requirements. All batches are supported by comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.