Description

3,5-Bis(Trifluoromethyl)Benzonitrile is a high-value fluorinated aromatic building block characterized by its two electron-withdrawing trifluoromethyl groups and a reactive nitrile functionality. This compound is essential for introducing lipophilicity, metabolic stability, and unique electronic properties into advanced molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF3 groups enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and electronic materials requiring specific dielectric properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) and nucleophilic aromatic substitution to construct complex, fluorinated molecules.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzonitrile
CAS No.	27126-93-8
Molecular Formula	C9H3F6N
Molecular Weight	239.12 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzonitrile; 2,6-Bis(trifluoromethyl)benzonitrile; α,α,α,α',α',α'-Hexafluoro-3,5-xylyl cyanide; 3,5-Bis(trifluoromethyl)phenyl cyanide; Benzonitrile, 3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)benzonitrile; 3,5-Bis(trifluoromethyl)benzenecarbonitrile
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.